Endocrine Abstracts

Oncogenic osteomalacia is a rare paraneoplastic phenomenon characterised by abnormal phosphate metabolism typically caused by discrete benign tumours. Due to the indolent presentation and slow progression, diagnosis is often delayed and localisation of the tumour can prove difficult. We present the case of a 64-years-old gentleman who was investigated by the endocrinology department for hypophosphataemia. Three years prior to this, he had started to experience exertional fatig...

Langerhans cell histiocytosis is a disease caused by clonal proliferation of a group of antigen-presenting cells known as Langerhans cells. Its manifestations range from isolated lesions to multisystem disease usually involving bone, skin and the pituitary stalk. Thyroid involvement is rare.A 44-year old woman presented to the joint thyroid clinic with a short history of neck swelling, confirmed to be a smooth goitre on clinical examination. Initial bloo...

Intracranial calcification seen on CT may be an incidental finding or it can be a direct cause of neurological symptoms depending on which areas of the brain are affected. The differential cause for the formation of intracranial calcium deposits include hypoparathyroidism, congenital infections i.e. toxoplasmosis and Fahr’s syndrome.A 50–year–old woman was referred to the transient ischaemic attack (TIA) clinic in December 2011, with recur...

Introduction: Graves’ disease (GD) is often treated with radioiodine therapy for cure. While, post external irradiation and post-radioiodine therapy (RAI) induced hyperparathyroidism after many years of latency is a well known phenomenon, there are only anectodal reports of post-radioiodine hypocalcemia. The factors contributing to this are poorly understood. In this context, we evaluated our own series to look deeper in to this issue.Material and m...

Introduction: Primary Hyperparathyroidism (PHPT) is a frequent endocrine disease which requires surgical excision for definitive cure. Apart from genetic role in its pathogenesis, there are conflicting reports about role of immunomodulation in literature. In this context, we set out study the role of Pro- inflammatory cytokines in PHPT in South Indian population.Material and methods: This prospective case-control study was conducted on surgically managed...

Introduction: Hashimoto’s thyroiditis (HT) is one of the commonest organ specific autoimmune thyroid disease. Though it is mostly treated medically, certain goitrous forms require surgical thyroidectomy for various indications. Autoimmunity has been implicated as one of the main cause of HT. In this context, we set out study the role of Pro- inflammatory cytokines in HT.Material and methods: This prospective case-control study was conducted on surgi...

Introduction: Contrary to the high prevalence of polycystic ovarian syndrome (PCOS) amongst reproductive age group women, there is disproportionate uncertainity over its etiopathogenesis. Substantial evidence suggests immunological-inflammatory role in causing this endocrine disorder. In this context, we set out study the role of inflammatory biomarkers in PCOS.Material and methods: This prospective case-control study was conducted on PCOS patients diagn...

Introduction: Nodular thyroid disease (NTD) is one of the commonest endocrine disease with incidence ranging from 5–30% in various populations Worldwide. They often require surgery for indications such as pressure symptoms or size related reasons. The natural history and etiopathogenesis are largely unclear except in few endemic regions. Immunomodulatory role has often been implicated in their pathogenesis. In this context, we set out study the association between Pro- in...

Introduction: The adenoma – carcinoma sequence in thyroid nodules is a enigmatic phenomenon. There are conflicting reports on development of papillary cancer from benign adenomas. Genomics is the only definitive modality to resolve this hypothesis. Adenomas and papillary carcinomas tend to have mutations in Sodium Iodide symporter gene (NIS) and highly specific BRAF gene respectively. In this context, we set out study the prevalence of these somatic mutations in surgical ...

Introduction: Papillary thyroid carcinoma (PTC) is the commonest endocrine malignancy. Apart from genetic role in its pathogenesis, autoimmunity has been implicated in certain papers. But, reports have been tripolar ranging from causative, protective and neutral role of immunomodulation. In this context, we set out study the role of Pro- inflammatory cytokines in PTC in South Indian population.Material and methods: This prospective case-control study was...